What is Interceptor Plus

What is Interceptor® Plus (milbemycin oxime/praziquantel), and what does it protect against?

Interceptor Plus is a monthly chewable tablet flavored with real chicken that prevents heartworm disease and treats and controls adult hookworm, roundworm, whipworm and tapeworm infections* in dogs and puppies 2 pounds of body weight or greater and 6 weeks of age and older. If you do not administer Interceptor Plus monthly throughout the year, continue administering the medication for at least 6 months following the last exposure to mosquitoes.

*Heartworm (D. immitis), hookworm (A. caninum), roundworm (T. canisT. leonina), whipworm (T. vulpis) and tapeworm (T. pisiformisE. multilocularis and E. granulosus)

What are some of the benefits of Interceptor Plus?

  • Interceptor Plus is an oral monthly product that is effective in preventing heartworm disease and treatment and control of adult hookworm (Ancylostoma caninum), adult roundworm and adult whipworm infections in dogs and puppies 2 pounds of body weight or greater and 6 weeks of age and older.
  • Interceptor Plus is approved by the FDA as safe and effective when used according to the label.
  • Interceptor Plus is available in four strengths. Each chewable flavored tablet is formulated to provide a minimum of 0.23 mg/pound (0.5 mg/kg) of milbemycin oxime and 2.28 mg/pound (5 mg/kg) of praziquantel.

Interceptor Plus dosing chart

How to give your dog Interceptor Plus

How well does Interceptor Plus work?

  • In a well-controlled laboratory study, Interceptor Plus was 100% effective against induced heartworm infections when administered once monthly for 6 consecutive months.
  • In well-controlled laboratory studies, neither one dose nor two consecutive doses of Interceptor Plus provided 100% effectiveness against induced heartworm infections.
  • Elimination of the adult stage of hookworm (A. caninum), roundworm (T. canis, T. leonina), whipworm (T. vulpis) and tapeworm (T. pisiformis, E. multilocularis, E. granulosus) infections in dogs was demonstrated in well-controlled laboratory studies.

What are the active ingredients in Interceptor Plus chewable tablets?

Milbemycin oxime and praziquantel are the two active ingredients in Interceptor Plus.

What is the flavoring in Interceptor Plus tablets?

Interceptor Plus is flavored with real chicken.

Is Interceptor Plus FDA approved?

Is Interceptor Plus safe?

Interceptor Plus is approved by the FDA for use in dogs and puppies 2 pounds of body weight or greater and 6 weeks of age and older. To receive FDA approval, Interceptor Plus was tested in hundreds of dogs and detailed clinical reports were submitted for intense review. Adverse events are reported to the FDA, and concerns are thoroughly investigated.

You should discuss the use of Interceptor Plus with your veterinarian prior to use if your dog has a history of epilepsy (seizures).

Is it safe to give my breeding dogs Interceptor Plus?

Ask your veterinarian about the use of Interceptor Plus prior to use in breeding dogs. The safe use of Interceptor Plus has not been evaluated in dogs used for breeding or in lactating females.

What side effects might occur with Interceptor Plus?

The following adverse reactions have been reported in dogs after administration of milbemycin oxime or praziquantel: vomiting, diarrhea, depression/lethargy, ataxia, anorexia, convulsions, weakness, and salivation.

Prior to administration of Interceptor Plus, dogs should be tested for existing heartworm infections. At the discretion of the veterinarian, infected dogs should be treated to remove adult heartworms. Interceptor Plus is not effective against adult D. immitis. Mild, transient hypersensitivity reactions, such as labored breathing, vomiting, hypersalivation and lethargy have been noted in some dogs treated with milbemycin oxime carrying a high number of circulating microlariae. These reactions are presumably caused by release of protein from dead or dying microlariae.

Will Interceptor Plus kill heartworms?

Interceptor Plus prevents heartworm disease by killing heartworms in certain stages of the heartworm lifecycle that develop after an infected mosquito bites a dog. As with other heartworm preventatives, Interceptor Plus does not kill adult heartworms. Speak to your veterinarian about treatment options if your dog is diagnosed with an adult heartworm infection.

Which heartworm lifecycle phase does Interceptor Plus control?

Interceptor Plus acts in the same way as other monthly heartworm preventatives by killing L3 and L4 larval stages before the larvae molt to the final adult stage.

Does Interceptor Plus protect against ticks?

Interceptor Plus is not labeled to kill or repel ticks. Interceptor Plus is labeled for the prevention of heartworm disease and to treat and control adult hookworm, roundworm, whipworm and tapeworm* infections. There are no known contraindications between Interceptor Plus and medications commonly used against ticks at labeled doses.

*Hookworm (A. caninum), roundworm (T. canis, T. leonina), whipworm (T. vulpis) and tapeworm (T. pisiformis, E. multilocularis, E. granulosus)

My dog has tapeworms. Will Interceptor Plus get rid of those?

Yes, Interceptor Plus treats tapeworm infections caused by Taenia pisiformis, Echinococcus multilocularis and Echinococcus granulosus.